ABSTRACT
Objective Using IPA rate to assess platelet reactivity of coronary heart disease patients re-ceived the dual antiplatelet therapy after PCI. Methods CHD patients received the loading dose of clopidogrel (300 mg)on the first day of hospitalization or before PCI,then received clopidogrel(75 mg/d)and aspirin(100 mg/d) for one year. IPA was measured after administration of the loading dose of clopidogrel. The patients were divided into the HPR and LPR group according to the rate of IPA. Observe patients incidences of cardiovascular events were followed up for one year. Results A total of 102 patients were enrolled into this study ,including 77 males and 25 females with average age of 65.7 ± 10.9. Patients were divided into the HPR and LPR group with 69 and 33 patients,respectively. The average IPA value of HPR group was obvious lower than that of LPR group(P<0.01). The accumulative 12-month cardiovascular events incidence in the HPR and LPR group were 15.9% and 3.0% respectively ,with significant difference (P < 0.05). Conclusion IPA could be used to evaluate platelet reactivity,which suggests that clinicians can detect IPA to reduce or avoid the recurrence of cardiovascular events.
ABSTRACT
Objective Using IPA rate to assess platelet reactivity of coronary heart disease patients re-ceived the dual antiplatelet therapy after PCI. Methods CHD patients received the loading dose of clopidogrel (300 mg)on the first day of hospitalization or before PCI,then received clopidogrel(75 mg/d)and aspirin(100 mg/d) for one year. IPA was measured after administration of the loading dose of clopidogrel. The patients were divided into the HPR and LPR group according to the rate of IPA. Observe patients incidences of cardiovascular events were followed up for one year. Results A total of 102 patients were enrolled into this study ,including 77 males and 25 females with average age of 65.7 ± 10.9. Patients were divided into the HPR and LPR group with 69 and 33 patients,respectively. The average IPA value of HPR group was obvious lower than that of LPR group(P<0.01). The accumulative 12-month cardiovascular events incidence in the HPR and LPR group were 15.9% and 3.0% respectively ,with significant difference (P < 0.05). Conclusion IPA could be used to evaluate platelet reactivity,which suggests that clinicians can detect IPA to reduce or avoid the recurrence of cardiovascular events.
ABSTRACT
Objective To observe the alteration of coagulation function in the patients with stage Ⅲ～Ⅳ non-Hodgkin lymphoma and evaluate its clinical significance. Methods 62 patients with NHL and 20 healthy examiners were studied. The parameters of PT, APTT, TT and FIB in blood plasma were detected.Results The levels of APTT and FIB in NHL group were significantly higher than that in control group (P 0.05).Conclusion The NHL patients especially ⅢB～ⅣB patients usually accompany with abnormal coagulation function and hypercoagnlable states, and it' s necessary to monitor their coagulation function.
ABSTRACT
Objective To investigate the expression and clinical significance of platelet activating factor [PAC]-1, CD62P and TPP hi severe sepsis. Method Patients with severe sepsis who were admitted into the EICU of Subei People's Hospital from April 2007 to March 2008 were included. Patients with severe sepsis (Group Ⅲ)were treated according to the treatment guidelines for severe sepsis, and were divided, according to their clinical records, into those who survived and those who died within 28 days of admission. Patients admitted during the same period with symptoms of infection but without severe sepsis were included as the General Infected Group (Group Ⅱ). A Control Group (Group Ⅰ) comprised patients who visited the hospital over the same period for physical examination or the healthy volunteers. The group members were all included randomly, and the gender and sex of patients in all three groups were similar. Patients with acute brain infarction, acute coronary syndrome,serious diabetes, hyperlipidemia, malignant tumor, leukemia, primary liver, renal and hematopoietic system dis-eases,long-term bedridden patients, pregnant women, and patients taking hormone treatment or hranunosuppres-sants were excluded from the study. Morning venous blood was collected and ELISA and Flow Cytometry performed on the fwst day of admission for Groups Ⅰ- and Ⅱ, and on the first, third and fifth day after admission for Group Ⅲ, to determine the TpP,PAC-1 and CD62P respectively; and the Marshall score was determined. Data were ana-lyzed by SPSS 12.0 software. For continuous variables, comparisons among groups were analyzed by ANOVA.Levene's and LSD test were applied to assess homogeneity. Bivariate test is applied to Correlation Analysis. P<0.05 was regarded as a statistically significant difference. Results There were a total of 20 patients each in GroupⅠ-and GroupⅡ, and 30 in Group Ⅲ; of these, 19 were classed as survivors and 11 died during the 28-day peri-od. On the first day of admission, there were no significant differences in PAC-1, CD62P or TpP expression between Groups Ⅰ- and Ⅱ(P>0.05); however, Group Ⅲ was significantly different compared with both Group Ⅰ and Group Ⅱ (both:P<0.05). The expression of PAC-1, CD62P and TpP tended to decline in the survivor group,and became normal with the treatment process, while the expression of PAC-1 ,CD62P and TpP in the patients who died remained high, and even increased significantly over time. On the first day, the expression of CD62P and TpP in the patients who survived and in those who died was not significantly different (P>0.05); on the third day,however, a significant difference appeared with values of (2.89±1.48) % vs. (5.04±2.57) % (P<0.01) for CD62P, and (5.24±2.22) mg/L vs. (9.20±1.93) mg/L (P<0.01) for TpP. The expression of PAC-1 was significantly different between the two subgroups on the first day, with values of (3.15±0.42)% vs. (5.30±.48)% (P<0.01). The Marshall score of the two groups showed similar changes. Correlation analysis showed that PAC-1, CD62P and TpP were significantly correlated with the Marshall score. Conclusions Platelet activation and microthrombosis existing in the early stage of severe sepsis work together in the early hypercoagulable state.They both play important roles in disease development and progression. The dynamic detection of CD62P and TpP is beneficial to the diagnosis and prognosis of severe sepsis.PAC-1 appears to hold a risk stratification effect, as pa-tients with high expression of PAC-1 in the early stage show poor prognosis. Therefore, PAC-1 could be used as a marker of severe sepsis and poor prognsis.